Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance

Targeted therapy against the epidermal growth factor receptor (EGFR) is one of the most promising molecular therapeutics for head and neck squamous cell carcinoma (HNSCC). EGFR is overexpressed in a wide range of malignancies, including HNSCC, and initiates important signal transduction pathways in...

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Bibliographic Details
Main Authors: Boeckx, Carolien, Baay, Marc, Wouters, An, Specenier, Pol, Vermorken, Jan B., Peeters, Marc, Lardon, Filip
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2013
Subjects:
Head and Neck Cancers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720640/
https://ncbi.nlm.nih.gov/pubmed/23821327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2013-0013
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