Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response

BACKGROUND: Targeted therapy against the Epidermal Growth Factor Receptor (EGFR) is among the most promising molecular therapeutics for Head and Neck Squamous Cell Carcinoma (HNSCC). However, drug resistance limits the clinical efficacy of anti-EGFR monoclonal antibodies and no predictive biomarker...

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Detalhes bibliográficos
Main Authors: Boeckx, Carolien, Weyn, Christine, Vanden Bempt, Isabelle, Deschoolmeester, Vanessa, Wouters, An, Specenier, Pol, Van Laer, Carl, Van den Weyngaert, Danielle, Kockx, Mark, Vermorken, Jan B, Peeters, Marc, Pauwels, Patrick, Lardon, Filip, Baay, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067106/
https://ncbi.nlm.nih.gov/pubmed/24899223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-337
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