Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress

The compound APR-246 (PRIMA-1(MET)) is a known reactivator of (mutant) p53 and inducer of oxidative stress which can sensitize cancer cells to platinum-based chemotherapeutics. However, the effect of a hypoxic tumor environment has been largely overlooked in this interaction. This study focusses on...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancers (Basel)
Päätekijät: Deben, Christophe, Deschoolmeester, Vanessa, De Waele, Jorrit, Jacobs, Julie, Van den Bossche, Jolien, Wouters, An, Peeters, Marc, Rolfo, Christian, Smits, Evelien, Lardon, Filip, Pauwels, Patrick
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923381/
https://ncbi.nlm.nih.gov/pubmed/29690507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10040126
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia