Hypoxia-Induced Cisplatin Resistance in Non-Small Cell Lung Cancer Cells Is Mediated by HIF-1α and Mutant p53 and Can Be Overcome by Induction of Oxidative Stress

The compound APR-246 (PRIMA-1(MET)) is a known reactivator of (mutant) p53 and inducer of oxidative stress which can sensitize cancer cells to platinum-based chemotherapeutics. However, the effect of a hypoxic tumor environment has been largely overlooked in this interaction. This study focusses on...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Deben, Christophe, Deschoolmeester, Vanessa, De Waele, Jorrit, Jacobs, Julie, Van den Bossche, Jolien, Wouters, An, Peeters, Marc, Rolfo, Christian, Smits, Evelien, Lardon, Filip, Pauwels, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923381/
https://ncbi.nlm.nih.gov/pubmed/29690507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10040126
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