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Epistasis in a fitness landscape defined by antibody-antigen binding free energy

Epistasis is the phenomenon by which the effect of a mutation depends on its genetic background. While it is usually defined in terms of organismal fitness, for single proteins it must reflect physical interactions among residues. Here, we systematically extract the specific contribution pairwise ep...

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Publicat a:Cell Syst
Autors principals: Adams, Rhys M., Kinney, Justin B., Walczak, Aleksandra M., Mora, Thierry
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487650/
https://ncbi.nlm.nih.gov/pubmed/30611676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.12.004
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