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The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography

The effect of a mutation on the organism often depends on what other mutations are already present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise epistatic effects have been recognized for over a century, and their evolutionary implications have received theo...

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Detalhes bibliográficos
Publicado no:J Stat Phys
Main Authors: Weinreich, Daniel M., Lan, Yinghong, Jaffe, Jacob, Heckendorn, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986866/
https://ncbi.nlm.nih.gov/pubmed/29904213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10955-018-1975-3
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