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Epistasis in a fitness landscape defined by antibody-antigen binding free energy
Epistasis is the phenomenon by which the effect of a mutation depends on its genetic background. While it is usually defined in terms of organismal fitness, for single proteins it must reflect physical interactions among residues. Here, we systematically extract the specific contribution pairwise ep...
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| Vydáno v: | Cell Syst |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487650/ https://ncbi.nlm.nih.gov/pubmed/30611676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.12.004 |
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