Opposing roles of CB(1) and CB(2) cannabinoid receptors in the stimulant and rewarding effects of cocaine

BACKGROUND AND PURPOSE: The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB(1) and CB(2) cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB(1) receptor a...

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Pubblicato in:Br J Pharmacol
Autori principali: Gobira, Pedro H, Oliveira, Ana C, Gomes, Julia S, da Silveira, Vivian T, Asth, Laila, Bastos, Juliana R, Batista, Edleusa M, Issy, Ana C, Okine, Bright N, de Oliveira, Antonio C, Ribeiro, Fabiola M, Del Bel, Elaine A, Aguiar, Daniele C, Finn, David P, Moreira, Fabricio A
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Themed Section: Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487550/
https://ncbi.nlm.nih.gov/pubmed/30101419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14473
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