Opposing roles of CB(1) and CB(2) cannabinoid receptors in the stimulant and rewarding effects of cocaine

BACKGROUND AND PURPOSE: The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB(1) and CB(2) cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB(1) receptor a...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Gobira, Pedro H, Oliveira, Ana C, Gomes, Julia S, da Silveira, Vivian T, Asth, Laila, Bastos, Juliana R, Batista, Edleusa M, Issy, Ana C, Okine, Bright N, de Oliveira, Antonio C, Ribeiro, Fabiola M, Del Bel, Elaine A, Aguiar, Daniele C, Finn, David P, Moreira, Fabricio A
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Themed Section: Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487550/
https://ncbi.nlm.nih.gov/pubmed/30101419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14473
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