Opposing roles of CB(1) and CB(2) cannabinoid receptors in the stimulant and rewarding effects of cocaine

BACKGROUND AND PURPOSE: The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB(1) and CB(2) cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB(1) receptor a...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gobira, Pedro H, Oliveira, Ana C, Gomes, Julia S, da Silveira, Vivian T, Asth, Laila, Bastos, Juliana R, Batista, Edleusa M, Issy, Ana C, Okine, Bright N, de Oliveira, Antonio C, Ribeiro, Fabiola M, Del Bel, Elaine A, Aguiar, Daniele C, Finn, David P, Moreira, Fabricio A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487550/
https://ncbi.nlm.nih.gov/pubmed/30101419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14473
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