Opposing roles of CB(1) and CB(2) cannabinoid receptors in the stimulant and rewarding effects of cocaine

BACKGROUND AND PURPOSE: The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB(1) and CB(2) cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB(1) receptor a...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Gobira, Pedro H, Oliveira, Ana C, Gomes, Julia S, da Silveira, Vivian T, Asth, Laila, Bastos, Juliana R, Batista, Edleusa M, Issy, Ana C, Okine, Bright N, de Oliveira, Antonio C, Ribeiro, Fabiola M, Del Bel, Elaine A, Aguiar, Daniele C, Finn, David P, Moreira, Fabricio A
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Themed Section: Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487550/
https://ncbi.nlm.nih.gov/pubmed/30101419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14473
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