Opposing roles of CB(1) and CB(2) cannabinoid receptors in the stimulant and rewarding effects of cocaine

BACKGROUND AND PURPOSE: The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB(1) and CB(2) cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB(1) receptor a...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Gobira, Pedro H, Oliveira, Ana C, Gomes, Julia S, da Silveira, Vivian T, Asth, Laila, Bastos, Juliana R, Batista, Edleusa M, Issy, Ana C, Okine, Bright N, de Oliveira, Antonio C, Ribeiro, Fabiola M, Del Bel, Elaine A, Aguiar, Daniele C, Finn, David P, Moreira, Fabricio A
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Themed Section: Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487550/
https://ncbi.nlm.nih.gov/pubmed/30101419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14473
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