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Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics
[Image: see text] CRISPR-Cas9 is the state-of-the-art technology for editing and manipulating nucleic acids. However, the occurrence of off-target mutations can limit its applicability. Here, all-atom enhanced molecular dynamics (MD) simulations—using Gaussian accelerated MD (GaMD)—are used to decip...
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| Publicado no: | ACS Cent Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2019
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487449/ https://ncbi.nlm.nih.gov/pubmed/31041385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00020 |
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