Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Understanding the conformational dynamics of CRISPR (clustered regularly interspaced short palindromic repeat)–Cas9 is of the utmost importance for improving its genome editing capability. Here, molecular dynamics simulations performed using Anton-2 – a specialized supercomputer capturing micro-to-m...

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Vydáno v:Q Rev Biophys
Hlavní autoři: Palermo, Giulia, Chen, Janice S., Ricci, Clarisse G., Rivalta, Ivan, Jinek, Martin, Batista, Victor S., Doudna, Jennifer A., McCammon, J. Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292676/
https://ncbi.nlm.nih.gov/pubmed/30555184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033583518000070
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