Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

[Image: see text] CRISPR-Cas9 is the state-of-the-art technology for editing and manipulating nucleic acids. However, the occurrence of off-target mutations can limit its applicability. Here, all-atom enhanced molecular dynamics (MD) simulations—using Gaussian accelerated MD (GaMD)—are used to decip...

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Pubblicato in:ACS Cent Sci
Autori principali: Ricci, Clarisse G., Chen, Janice S., Miao, Yinglong, Jinek, Martin, Doudna, Jennifer A., McCammon, J. Andrew, Palermo, Giulia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487449/
https://ncbi.nlm.nih.gov/pubmed/31041385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00020
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