Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9

[Image: see text] CRISPR-Cas9 is a genome editing technology with major impact in life sciences. In this system, the endonuclease Cas9 generates double strand breaks in DNA upon RNA-guided recognition of a complementary DNA sequence, which strictly requires the presence of a protospacer adjacent mot...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Palermo, Giulia, Ricci, Clarisse G., Fernando, Amendra, Basak, Rajshekhar, Jinek, Martin, Rivalta, Ivan, Batista, Victor S., McCammon, J. Andrew
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905990/
https://ncbi.nlm.nih.gov/pubmed/28764328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05313
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