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Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity

Amyotrophic lateral sclerosis is a deleterious neurodegenerative disease without effective treatment options. Recent studies have indicated the involvement of the dysregulation of RNA metabolism in the pathogenesis of amyotrophic lateral sclerosis. Among the various RNA regulatory machineries, nonse...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Brain
Asıl Yazarlar: Xu, Wangchao, Bao, Puhua, Jiang, Xin, Wang, Haifang, Qin, Meiling, Wang, Ruiqi, Wang, Tao, Yang, Yi, Lorenzini, Ileana, Liao, Lujian, Sattler, Rita, Xu, Jin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487333/
https://ncbi.nlm.nih.gov/pubmed/30938419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz070
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