UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G(4)C(2)) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD). Here, we investigate the role that overexpression of UPF1, a protein involved in NMD, plays...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Zaepfel, Benjamin L., Zhang, Zhe, Maulding, Kirstin, Coyne, Alyssa N., Cheng, Weiwei, Hayes, Lindsey R., Lloyd, Thomas E., Sun, Shuying, Rothstein, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063722/
https://ncbi.nlm.nih.gov/pubmed/33789100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108925
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