Structural basis for auxiliary subunit KCTD16 regulation of the GABA(B) receptor

Metabotropic GABA(B) receptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABA(B) receptor complexes contain the principal subunits GABA(B1) and GABA(B2), which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization d...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zuo, Hao, Glaaser, Ian, Zhao, Yulin, Kurinov, Igor, Mosyak, Lidia, Wang, Haonan, Liu, Jonathan, Park, Jinseo, Frangaj, Aurel, Sturchler, Emmanuel, Zhou, Ming, McDonald, Patricia, Geng, Yong, Slesinger, Paul A., Fan, Qing R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486783/
https://ncbi.nlm.nih.gov/pubmed/30971491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903024116
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