Opposite Effects of KCTD Subunit Domains on GABA(B) Receptor-mediated Desensitization

GABA(B) receptors assemble from principle and auxiliary subunits. The principle subunits GABA(B1) and GABA(B2) form functional heteromeric GABA(B(1,2)) receptors that associate with homotetramers of auxiliary KCTD8, -12, -12b, or -16 (named after their K(+) channel tetramerization domain) subunits....

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Autors principals: Seddik, Riad, Jungblut, Stefan P., Silander, Olin K., Rajalu, Mathieu, Fritzius, Thorsten, Besseyrias, Valérie, Jacquier, Valérie, Fakler, Bernd, Gassmann, Martin, Bettler, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501043/
https://ncbi.nlm.nih.gov/pubmed/23035119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412767
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