Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing

GABA(B) receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic...

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Publicat a:Nat Commun
Autors principals: Dinamarca, Margarita C., Raveh, Adi, Schneider, Andy, Fritzius, Thorsten, Früh, Simon, Rem, Pascal D., Stawarski, Michal, Lalanne, Txomin, Turecek, Rostislav, Choo, Myeongjeong, Besseyrias, Valérie, Bildl, Wolfgang, Bentrop, Detlef, Staufenbiel, Matthias, Gassmann, Martin, Fakler, Bernd, Schwenk, Jochen, Bettler, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430795/
https://ncbi.nlm.nih.gov/pubmed/30902970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09164-3
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