Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing

GABA(B) receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Dinamarca, Margarita C., Raveh, Adi, Schneider, Andy, Fritzius, Thorsten, Früh, Simon, Rem, Pascal D., Stawarski, Michal, Lalanne, Txomin, Turecek, Rostislav, Choo, Myeongjeong, Besseyrias, Valérie, Bildl, Wolfgang, Bentrop, Detlef, Staufenbiel, Matthias, Gassmann, Martin, Fakler, Bernd, Schwenk, Jochen, Bettler, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430795/
https://ncbi.nlm.nih.gov/pubmed/30902970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09164-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados