Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing

GABA(B) receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Dinamarca, Margarita C., Raveh, Adi, Schneider, Andy, Fritzius, Thorsten, Früh, Simon, Rem, Pascal D., Stawarski, Michal, Lalanne, Txomin, Turecek, Rostislav, Choo, Myeongjeong, Besseyrias, Valérie, Bildl, Wolfgang, Bentrop, Detlef, Staufenbiel, Matthias, Gassmann, Martin, Fakler, Bernd, Schwenk, Jochen, Bettler, Bernhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430795/
https://ncbi.nlm.nih.gov/pubmed/30902970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09164-3
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