Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing

GABA(B) receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic...

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Udgivet i:Nat Commun
Main Authors: Dinamarca, Margarita C., Raveh, Adi, Schneider, Andy, Fritzius, Thorsten, Früh, Simon, Rem, Pascal D., Stawarski, Michal, Lalanne, Txomin, Turecek, Rostislav, Choo, Myeongjeong, Besseyrias, Valérie, Bildl, Wolfgang, Bentrop, Detlef, Staufenbiel, Matthias, Gassmann, Martin, Fakler, Bernd, Schwenk, Jochen, Bettler, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430795/
https://ncbi.nlm.nih.gov/pubmed/30902970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09164-3
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