VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure

Prostaglandin E2 (PGE2) plays an important role in vascular homeostasis. Its receptor, E-prostanoid receptor 4 (EP4) is essential for physiological remodeling of the ductus arteriosus (DA). However, the role of EP4 in pathological vascular remodeling remains largely unknown. We found that chronic an...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Xu, Hu, Du, Shengnan, Fang, Bingying, Li, Chaojie, Jia, Xiao, Zheng, Senfeng, Wang, Sailun, Li, Qingwei, Su, Wen, Wang, Nanping, Zheng, Feng, Chen, Lihong, Zhang, Xiaoyan, Gustafsson, Jan-Åke, Guan, Youfei
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486760/
https://ncbi.nlm.nih.gov/pubmed/30948641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902119116
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