Endothelial cell prostaglandin E(2) receptor EP4 is essential for blood pressure homeostasis

Prostaglandin E(2) and its cognate EP1–4 receptors play important roles in blood pressure (BP) regulation. Herein, we show that endothelial cell–specific (EC-specific) EP4 gene–knockout mice (EC-EP4(–/–)) exhibited elevated, while EC-specific EP4-overexpression mice (EC-hEP4(OE)) displayed reduced,...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Xu, Hu, Fang, Bingying, Du, Shengnan, Wang, Sailun, Li, Qingwei, Jia, Xiao, Bao, Chengzhen, Ye, Lan, Sui, Xue, Qian, Lei, Luan, Zhilin, Yang, Guangrui, Zheng, Feng, Wang, Nanping, Chen, Lihong, Zhang, Xiaoyan, Guan, Youfei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406248/
https://ncbi.nlm.nih.gov/pubmed/32641583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138505
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