Endothelial cell prostaglandin E(2) receptor EP4 is essential for blood pressure homeostasis

Prostaglandin E(2) and its cognate EP1–4 receptors play important roles in blood pressure (BP) regulation. Herein, we show that endothelial cell–specific (EC-specific) EP4 gene–knockout mice (EC-EP4(–/–)) exhibited elevated, while EC-specific EP4-overexpression mice (EC-hEP4(OE)) displayed reduced,...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Xu, Hu, Fang, Bingying, Du, Shengnan, Wang, Sailun, Li, Qingwei, Jia, Xiao, Bao, Chengzhen, Ye, Lan, Sui, Xue, Qian, Lei, Luan, Zhilin, Yang, Guangrui, Zheng, Feng, Wang, Nanping, Chen, Lihong, Zhang, Xiaoyan, Guan, Youfei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406248/
https://ncbi.nlm.nih.gov/pubmed/32641583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138505
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