Inactivation of the EP3 receptor attenuates the Angiotensin II pressor response via decreasing arterial contractility

OBJECTIVE: The present studies aimed at elucidating the role of prostaglandin E(2) (PGE(2)) receptor subtype 3 (EP3) in regulating blood pressure. METHODS AND RESULTS: Mice bearing a genetic disruption of the EP3 gene (EP3−/−) exhibited reduced baseline mean arterial pressure monitored by both tail-...

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Autori principali: Chen, Lihong, Miao, Yifei, Zhang, Yahua, Dou, Dou, Liu, Limei, Tian, Xiaoyu, Yang, Guangrui, Pu, Dan, Zhang, Xiaoyan, Kang, Jihong, Gao, Yuansheng, Wang, Shiqiang, Breyer, Matthew D., Wang, Nanping, Zhu, Yi, Huang, Yu, Breyer, Richard M, Guan, Youfei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565847/
https://ncbi.nlm.nih.gov/pubmed/23065824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.254052
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