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Inactivation of the EP3 receptor attenuates the Angiotensin II pressor response via decreasing arterial contractility
OBJECTIVE: The present studies aimed at elucidating the role of prostaglandin E(2) (PGE(2)) receptor subtype 3 (EP3) in regulating blood pressure. METHODS AND RESULTS: Mice bearing a genetic disruption of the EP3 gene (EP3−/−) exhibited reduced baseline mean arterial pressure monitored by both tail-...
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| Главные авторы: | , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3565847/ https://ncbi.nlm.nih.gov/pubmed/23065824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.254052 |
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