Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress

Hypertonicity in renal medulla is critical for the kidney to produce concentrated urine. Renal medullary cells have to survive high medullary osmolarity during antidiuresis. Previous study reported that farnesoid X receptor (FXR), a nuclear receptor transcription factor activated by endogenous bile...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Sujuan, Huang, Shizheng, Luan, Zhilin, Chen, Tingyue, Wei, Yuanyi, Xing, Miaomiao, Li, Yaqing, Du, Chunxiu, Wang, Bing, Zheng, Feng, Wang, Nanping, Guan, Youfei, Gustafsson, Jan-Åke, Zhang, Xiaoyan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003498/
https://ncbi.nlm.nih.gov/pubmed/29739889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803945115
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