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Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress

Hypertonicity in renal medulla is critical for the kidney to produce concentrated urine. Renal medullary cells have to survive high medullary osmolarity during antidiuresis. Previous study reported that farnesoid X receptor (FXR), a nuclear receptor transcription factor activated by endogenous bile...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Xu, Sujuan, Huang, Shizheng, Luan, Zhilin, Chen, Tingyue, Wei, Yuanyi, Xing, Miaomiao, Li, Yaqing, Du, Chunxiu, Wang, Bing, Zheng, Feng, Wang, Nanping, Guan, Youfei, Gustafsson, Jan-Åke, Zhang, Xiaoyan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003498/
https://ncbi.nlm.nih.gov/pubmed/29739889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803945115
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