Stabilization of amyloidogenic immunoglobulin light chains by small molecules

In Ig light-chain (LC) amyloidosis (AL), the unique antibody LC protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. As a step toward developing treatments for AL patients with substantial cardiac involvement who hav...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Morgan, Gareth J., Yan, Nicholas L., Mortenson, David E., Rennella, Enrico, Blundon, Joshua M., Gwin, Ryan M., Lin, Chung-Yon, Stanfield, Robyn L., Brown, Steven J., Rosen, Hugh, Spicer, Timothy P., Fernandez-Vega, Virneliz, Merlini, Giampaolo, Kay, Lewis E., Wilson, Ian A., Kelly, Jeffery W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486714/
https://ncbi.nlm.nih.gov/pubmed/30971495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817567116
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