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Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function

p97/VCP, a member of the AAA+ (ATPases associated with diverse cellular activities) family of proteins, is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue as well as the central nervous system. Methyl-TROSY–based NMR studies have previously revealed ho...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schütz, Anne Kathrin, Rennella, Enrico, Kay, Lewis E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565461/
https://ncbi.nlm.nih.gov/pubmed/28760999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707974114
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