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AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization
Tripartite motif-containing 21 (TRIM21) is a cytosolic IgG receptor that mediates intracellular virus neutralization by antibody. TRIM21 targets virions for destruction in the proteasome, but it is unclear how a substrate as large as a viral capsid is degraded. Here, we identify the ATPase p97/valos...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3511720/ https://ncbi.nlm.nih.gov/pubmed/23091005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210659109 |
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