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Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular immune response that disables virions in the cytosol. We have discovered that ce...

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Main Authors: Mallery, Donna L., McEwan, William A., Bidgood, Susanna R., Towers, Greg J., Johnson, Chris M., James, Leo C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993423/
https://ncbi.nlm.nih.gov/pubmed/21045130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014074107
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