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Intracellular antibody-bound pathogens stimulate immune signaling via Fc-receptor TRIM21
Antibodies can be carried into the cell during pathogen infection where they are detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we show that TRIM21 recognition of intracellular antibodies activates immune signaling. TRIM21 catalyses K63-ubiquitin chain formation, sti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672961/ https://ncbi.nlm.nih.gov/pubmed/23455675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2548 |
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