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Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function
p97/VCP, a member of the AAA+ (ATPases associated with diverse cellular activities) family of proteins, is implicated in the etiology of a group of degenerative diseases affecting bone and muscle tissue as well as the central nervous system. Methyl-TROSY–based NMR studies have previously revealed ho...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565461/ https://ncbi.nlm.nih.gov/pubmed/28760999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707974114 |
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