The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential for the one-carbon metabolism, which sustains growth and proliferation in...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Guiducci, Giulia, Paone, Alessio, Tramonti, Angela, Giardina, Giorgio, Rinaldo, Serena, Bouzidi, Amani, Magnifico, Maria C, Marani, Marina, Menendez, Javier A, Fatica, Alessandro, Macone, Alberto, Armaos, Alexandros, Tartaglia, Gian G, Contestabile, Roberto, Paiardini, Alessandro, Cutruzzolà, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
RNA and RNA-protein complexes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486632/
https://ncbi.nlm.nih.gov/pubmed/30809670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz129
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