MRE11 UFMylation promotes ATM activation

A proper DNA damage response (DDR) is essential to maintain genome integrity and prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion and their repair is orchestrated by the ATM kinase. ATM is activated via the MRE11–RAD50–NBS1 (MRN) complex along with its autophospho...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wang, Zhifeng, Gong, Yamin, Peng, Bin, Shi, Ruifeng, Fan, Dan, Zhao, Hongchang, Zhu, Min, Zhang, Haoxing, Lou, Zhenkun, Zhou, Jianwei, Zhu, Wei-Guo, Cong, Yu-Sheng, Xu, Xingzhi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486557/
https://ncbi.nlm.nih.gov/pubmed/30783677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz110
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