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MRE11 UFMylation promotes ATM activation
A proper DNA damage response (DDR) is essential to maintain genome integrity and prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion and their repair is orchestrated by the ATM kinase. ATM is activated via the MRE11–RAD50–NBS1 (MRN) complex along with its autophospho...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6486557/ https://ncbi.nlm.nih.gov/pubmed/30783677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz110 |
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