S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex

Double-strand breaks (DSBs) in chromosomes are the most challenging type of DNA damage. The yeast and mammalian Mre11-Rad50-Xrs2/Nbs1 (MRX/N)-Sae2/Ctp1 complex catalyzes the resection of DSBs induced by secondary structures, chemical adducts or covalently-attached proteins. MRX/N also initiates two...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Chen, Yu-Jie, Chuang, Yu-Chien, Chuang, Chi-Ning, Cheng, Yun-Hsin, Chang, Chuang-Rung, Leng, Chih-Hsiang, Wang, Ting-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797280/
https://ncbi.nlm.nih.gov/pubmed/26743002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1523
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