Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation

Bone osteogenic sarcoma has a poor prognosis, as the exact cell of origin and the signaling pathways underlying tumor formation remain undefined. Here, we report an osteogenic tumor mouse model based on the conditional knockout of liver kinase b1 (Lkb1, also known as Stk11) in Cathepsin K–Cre–expres...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Han, Yujiao, Feng, Heng, Sun, Jun, Liang, Xiaoting, Wang, Zhuo, Xing, Wenhui, Dai, Qinggang, Yang, Yang, Han, Anjia, Wei, Zhanying, Bi, Qing, Ji, Hongbin, Kang, Tiebang, Zou, Weiguo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486357/
https://ncbi.nlm.nih.gov/pubmed/30830877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124590
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