Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

Mammalian target of rapamycin complex 1 (mTORC1) is involved in anabolic metabolism in both osteoblasts and chondrocytes, but the role of mTORC1 in osteoclast biology in vivo remains to be elucidated. In this study, we showed that deletion of regulatory-associated protein of mTOR (Raptor) in osteocl...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dai, Qinggang, Xie, Furong, Han, Yujiao, Ma, Xuhui, Zhou, Siru, Jiang, Lingyong, Zou, Weiguo, Wang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217679/
https://ncbi.nlm.nih.gov/pubmed/27879318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764761
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