Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

Mammalian target of rapamycin complex 1 (mTORC1) is involved in anabolic metabolism in both osteoblasts and chondrocytes, but the role of mTORC1 in osteoclast biology in vivo remains to be elucidated. In this study, we showed that deletion of regulatory-associated protein of mTOR (Raptor) in osteocl...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Dai, Qinggang, Xie, Furong, Han, Yujiao, Ma, Xuhui, Zhou, Siru, Jiang, Lingyong, Zou, Weiguo, Wang, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217679/
https://ncbi.nlm.nih.gov/pubmed/27879318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764761
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