Dynamic Kinetochore Size Regulation Promotes Microtubule Capture and Chromosome Biorientation in Mitosis

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to form a fibrous corona, and compacts upon microtubule capture. Here we show that the dynein adaptor Spindly and the...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Sacristan, Carlos, Ahmad, Misbha Ud Din, Keller, Jenny, Fermie, Job, Groenewold, Vincent, Tromer, Eelco, Fish, Alexander, Melero, Roberto, Carazo, José María, Klumperman, Judith, Musacchio, Andrea, Perrakis, Anastassis, Kops, Geert JPL
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485389/
https://ncbi.nlm.nih.gov/pubmed/29915359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0130-3
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