Dynamic Kinetochore Size Regulation Promotes Microtubule Capture and Chromosome Biorientation in Mitosis

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to form a fibrous corona, and compacts upon microtubule capture. Here we show that the dynein adaptor Spindly and the...

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Bibliografske podrobnosti
izdano v:Nat Cell Biol
Main Authors: Sacristan, Carlos, Ahmad, Misbha Ud Din, Keller, Jenny, Fermie, Job, Groenewold, Vincent, Tromer, Eelco, Fish, Alexander, Melero, Roberto, Carazo, José María, Klumperman, Judith, Musacchio, Andrea, Perrakis, Anastassis, Kops, Geert JPL
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485389/
https://ncbi.nlm.nih.gov/pubmed/29915359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0130-3
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