Dynamic Kinetochore Size Regulation Promotes Microtubule Capture and Chromosome Biorientation in Mitosis

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to form a fibrous corona, and compacts upon microtubule capture. Here we show that the dynein adaptor Spindly and the...

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Publicado en:Nat Cell Biol
Main Authors: Sacristan, Carlos, Ahmad, Misbha Ud Din, Keller, Jenny, Fermie, Job, Groenewold, Vincent, Tromer, Eelco, Fish, Alexander, Melero, Roberto, Carazo, José María, Klumperman, Judith, Musacchio, Andrea, Perrakis, Anastassis, Kops, Geert JPL
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485389/
https://ncbi.nlm.nih.gov/pubmed/29915359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0130-3
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