Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans. By specifying that APAP metabolism, reactive metabolite formation, glutathione depletion, and mitigation of mitochondrial damage within indi...

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Udgivet i:Toxicol Sci
Main Authors: Kennedy, Ryan C, Smith, Andrew K, Ropella, Glen E P, McGill, Mitchell R, Jaeschke, Hartmut, Hunt, C Anthony
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Intercellular Communication in Acetaminophen-Induced Pericentral Necrosis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484890/
https://ncbi.nlm.nih.gov/pubmed/30698817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz029
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