Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial

IMPORTANCE: Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis–related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Sio, Terence T., Le-Rademacher, Jennifer G., Leenstra, James L., Loprinzi, Charles L., Rine, Grant, Curtis, Amarinthia, Singh, Anurag K., Martenson, James A., Novotny, Paul J., Tan, Angelina D., Qin, Rui, Ko, Stephen J., Reiter, Paul L., Miller, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484809/
https://ncbi.nlm.nih.gov/pubmed/30990550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.3504
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