Doxepin Rinse Versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy With or Without Chemotherapy: A Phase III, Randomized, Double-Blind Trial (NCCTG-N09C6 [Alliance])

PURPOSE: Painful oral mucositis (OM) is a significant toxicity during radiotherapy for head and neck cancers. The aim of this randomized, double-blind, placebo-controlled trial was to test the efficacy of doxepin hydrochloride in the reduction of radiotherapy-induced OM pain. PATIENTS AND METHODS: I...

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Autors principals: Leenstra, James L., Miller, Robert C., Qin, Rui, Martenson, James A., Dornfeld, Kenneth J., Bearden, James D., Puri, Dev R., Stella, Philip J., Mazurczak, Miroslaw A., Klish, Marie D., Novotny, Paul J., Foote, Robert L., Loprinzi, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2014
Matèries:
ORIGINAL REPORTS
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026580/
https://ncbi.nlm.nih.gov/pubmed/24733799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.53.2630
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