Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial

IMPORTANCE: Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis–related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used. OBJECTIVE: To evaluate the effect...

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Dades bibliogràfiques
Publicat a:JAMA
Autors principals: Sio, Terence T., Le-Rademacher, Jennifer G., Leenstra, James L., Loprinzi, Charles L., Rine, Grant, Curtis, Amarinthia, Singh, Anurag K., Martenson, James A., Novotny, Paul J., Tan, Angelina D., Qin, Rui, Ko, Stephen J., Reiter, Paul L., Miller, Robert C.
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2019
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484809/
https://ncbi.nlm.nih.gov/pubmed/30990550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2019.3504
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