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QueE: A radical SAM enzyme involved in the biosynthesis of 7-deazapurine containing natural products

7-Carboxy-7-deazaguanine (CDG) is a common intermediate in the biosynthesis of 7-deazapurine-contianing natural products. The biosynthesis of CDG from GTP requires three enzymes: GTP cyclohydrolase I, 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)) synthase, and CDG synthase (QueE). QueE is a member of...

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Detalles Bibliográficos
Publicado en:Methods Enzymol
Autores principales: Lewis, Julia K., Bruender, Nathan A., Bandarian, Vahe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484087/
https://ncbi.nlm.nih.gov/pubmed/30097106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2018.05.001
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