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Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism
7-Carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg(2+)-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a member of the AdoMet radical superfamily, which empl...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3939041/ https://ncbi.nlm.nih.gov/pubmed/24362703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1426 |
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