Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

7-Carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg(2+)-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a member of the AdoMet radical superfamily, which empl...

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Main Authors: Dowling, Daniel P., Bruender, Nathan A., Young, Anthony P., McCarty, Reid M., Bandarian, Vahe, Drennan, Catherine L.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939041/
https://ncbi.nlm.nih.gov/pubmed/24362703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1426
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