7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies

[Image: see text] Radical S-adenosyl-l-methionine (SAM) enzymes are widely distributed and catalyze diverse reactions. SAM binds to the unique iron atom of a site-differentiated [4Fe-4S] cluster and is reductively cleaved to generate a 5′-deoxyadenosyl radical, which initiates turnover. 7-Carboxy-7-...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Bruender, Nathan A., Grell, Tsehai A. J., Dowling, Daniel P., McCarty, Reid M., Drennan, Catherine L., Bandarian, Vahe
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301278/
https://ncbi.nlm.nih.gov/pubmed/28045519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11381
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