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Crystal structure of AdoMet radical enzyme 7‐carboxy‐7‐deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe–4S] cluster engender flavodoxin specificity

7‐Carboxy‐7‐deazaguanine synthase, QueE, catalyzes the radical mediated ring contraction of 6‐carboxy‐5,6,7,8‐tetrahydropterin, forming the characteristic pyrrolopyrimidine core of all 7‐deazaguanine natural products. QueE is a member of the S‐adenosyl‐L‐methionine (AdoMet) radical enzyme superfamil...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Grell, Tsehai A.J., Bell, Benjamin N., Nguyen, Chi, Dowling, Daniel P., Bruender, Nathan A., Bandarian, Vahe, Drennan, Catherine L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295903/
https://ncbi.nlm.nih.gov/pubmed/30341796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3529
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