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Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine Synthase

The radical S-adenosyl-l-methionine (SAM) superfamily is a large and growing group of enzymes that carry out complex radical-mediated transformations. A one-electron reduction of SAM via the +1 state of the cubane [4Fe-4S] cluster generates a 5′-deoxyadenosyl radical, which initiates turnover. The [...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Bruender, Nathan A., Young, Anthony P., Bandarian, Vahe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774511/
https://ncbi.nlm.nih.gov/pubmed/25933252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00210
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