Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca(2+) Leakage from the Endoplasmic Reticulum

Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca(2+) homeostasis by enhancing the Ca(2+) leakage from mammalian ER. A c...

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Publicado no:Cell Chem Biol
Main Authors: Gamayun, Igor, O'Keefe, Sarah, Pick, Tillman, Klein, Marie-Christine, Nguyen, Duy, McKibbin, Craig, Piacenti, Michela, Williams, Helen M., Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia, Helms, Volkhard, High, Stephen, Zimmermann, Richard, Cavalié, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483976/
https://ncbi.nlm.nih.gov/pubmed/30799222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.01.010
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