Interaction of calmodulin with Sec61α limits Ca(2+) leakage from the endoplasmic reticulum

In eukaryotes, protein transport into the endoplasmic reticulum (ER) is facilitated by a protein-conducting channel, the Sec61 complex. The presence of large, water-filled pores with uncontrolled ion permeability, as formed by Sec61 complexes in the ER membrane, would seriously interfere with the re...

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Bibliografiske detaljer
Main Authors: Erdmann, Frank, Schäuble, Nico, Lang, Sven, Jung, Martin, Honigmann, Alf, Ahmad, Mazen, Dudek, Johanna, Benedix, Julia, Harsman, Anke, Kopp, Annika, Helms, Volkhard, Cavalié, Adolfo, Wagner, Richard, Zimmermann, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020109/
https://ncbi.nlm.nih.gov/pubmed/21102557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.284
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