BiP-mediated closing of the Sec61 channel limits Ca(2+) leakage from the ER

In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic protein-conducting channel, the Sec61 complex. Previous work has characterized the Sec61 channel as a potential ER Ca(2+) leak channel and identified calmodulin as limiting Ca(...

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Detalhes bibliográficos
Main Authors: Schäuble, Nico, Lang, Sven, Jung, Martin, Cappel, Sabine, Schorr, Stefan, Ulucan, Özlem, Linxweiler, Johannes, Dudek, Johanna, Blum, Robert, Helms, Volkhard, Paton, Adrienne W, Paton, James C, Cavalié, Adolfo, Zimmermann, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411083/
https://ncbi.nlm.nih.gov/pubmed/22796945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.189
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